Bitter Melon Extract/Memordica charantia L. CAS No.:90063-94-8

Specifications

Bitter melon Extract

 
Latin Name: Memordica charantia L.
Botanical Source: Memordica charantia L.
Part Used: Fruit
Appearance: Brown Yellow Powder
Active Ingredient: Total Charantin
Specification: 10-80%  Test Method: UV

Bitter Melon Extract is used in dietary supplements is derived from the fruit of Momordica charantia L.

Bitter Melon Extract used in dietary supplements is derived from the fruit of Momordica charantia L.
Bitter Melon Benefits
•  Anti-Diabetes (Hypoglycemia or Blood Glucose Lowering, adult-onset diabetes or type-II diabetes)
•  Anti-HIV
•  Psoriasis Treatment
•  Anti-obesity
•  Anti-malarial
•  Anti-cancer
•  Demulcent (Ache Relief)
•  Aphrodisiac

Folk wisdom has it that bitter melon helps to prevent or counteract type-II diabetes. And it also is reported to help in the treatment psoriasis. It has also been thought that Bitter Melon may help in the treatment of HIV, but the evidence thus far is too weak to even consider. The ripe fruit of Bitter Melon has been suggested to exhibit some remarkable anti-cancer effects, but there is absolutely no evidence that it can treat cancer. However, preliminary studies do appear to confirm that Bitter Melon may improve blood sugar control in people with adult-onset diabetes (type-II diabetes).

A recent scientific study at JIPMER, India has proved that bitter melon increases insulin sensitivity. Also, in 2007, the Philippine Department of Health issued a circular stating that bitter melon, as a scientifically validated herbal medicinal plant, can lower elevated blood sugar levels. The study revealed that a 100 milligram per kilo dose per day is comparable to 2.5 milligrams of the anti-diabetes drug Glibenclamide taken twice per day. Bitter melon is sold in the Philippines as a food supplement and marketed under the trade name Charantia. Charantia capsules and tea are being exported to the United States, Canada, Europe, Mexico, Japan, Korea, and parts of the Middle East.

There are a myriad of phytochemicals present in bitter melon and at least there are three different groups of constituents in bitter melon have been reported to have hypoglycemic (blood sugar lowering and regulating effects) or other actions of potential benefit in diabetes mellitus. These include a mixture of steroidal saponins(glucosides) known as Charantins (including Charartin, Cerebroside, Goyasaponins, and momordicosides), insulin-like peptides(Lectin), and alkaloids(called Momordicine). It is still unclear which of these is most effective, or if all three work together. Two proteins, known as alpha- and beta-momorcharin inhibit the AIDS virus, but this research has only been demonstrated in test tubes and not in humans. A constituent in bitter melon, as yet unidentified, inhibits the enzyme guanylate cyclase, an act that may benefit people with psoriasis.

The mixture of steroidal saponins(glucosides) known as Charantins (including Charartin, Cerebroside, Goyasaponins, and momordicosides, four very promising bioactive compounds that Bitter Melon contains) activate a protein called AMPK, which is well known for regulating fuel metabolism and enabling glucose uptake, processes which are impaired in diabetics. "We can now understand at a molecular level why bitter melon works as a treatment for diabetes," said David James, director of the diabetes and obesity program at the Garvan Institute of Medical Research in Sydney. "By isolating the compounds we believe to be therapeutic, we can investigate how they work together in our cells."

The lectin that has insulin-like bioactivity is due to its linking together 2 insulin receptors, and mimicking the action of animal insulin. This lectin lowers blood glucose concentrations by acting on peripheral tissues and, similar to insulin's effects in the brain, suppressing appetite. This lectin is likely a major contributor to the hypoglycemic effect that develops after eating bitter melon and why it may be a way of managing adult-onset diabetes. Lectin binding is non-protein specific, and this is likely why bitter melon has been credited with immunostimulatory activity - by linking receptors that modulate the immune system, thereby stimulating said receptors.

The alkaloids called Momordicine suppress neural response to sweet taste stimuli.

Safety

Bitter Melon Extract is safe, but various cautions are indicated. The seeds contain vicine and therefore can trigger symptoms of favism in susceptible individuals. In addition, the red arils of the seeds are reported to be toxic to children, and the fruit is contraindicated during pregnancy.

 Package: With double plastic bags in 25kg fiber drum or at customer's request.

Storage: Store in a cool, dry place and keep away from direct strong light.

Shelf Life:2 years.

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